Yuanan (Ron) Lu, PhD
Professor, Environmental Health

E-mail: ylu@pbrc.hawaii.edu

Academic Degrees
PhD (Microbiology), University of Hawai‘i at Mānoa
MS (Microbiology), Oregon State University
BS (Marine Biology), Huazhong Agricultural University

Honors & Association
? 1st Place Award for Faculty Division of the Biological Sciences Symposium, University of Hawai‘i
? Faculty Travel Awards, University Research Council, University of Hawai‘i, 2006 & 2007
? Scholarship Award from the National Science Academy Foundation, China, 2003
? Member of American Society for Virology
? Member of International Society of Neurovirology
? Member of American Association for Advancement of Sciences
? Member of the Society for Neuroimmune Pharmacology
? Member of American Society for World Aquaculture
? Member of Hawai‘i Public Health

Research Interests and Ongoing Projects
? Viral vectors and vector-mediated gene transfer and transgene expression in vitro and in vivo
? Novel gene therapy approaches for HIV-1 infection in the central nervous system l
? Marine compounds and their antiviral activities
? Test and production of transgenic shrimp strains with viral resistance
? New methods for enhanced monitoring costal water contamination using environmental pathogens as an indicator

Selected Publications
? Tan, F, M. Wang, W. Wang, and Y. Lu. 2008. Cytotoxicity sensitivity of six fish cell lines to four common heavy metals. Toxicology in Vitro. 22:164-170.
? Lu, Y. and L. Sniderhan. 2008. Viral vector mediated gene transfer. In: Schwab M. (editor), Encyclopedia of Cancer. 2nd Edition. Springer-Verlag Berlin Heidelberg, New York. pp 3169-3171. Pubmed 10.1007/978-3-540-47648-1_6193.
? Yang, Y.B., C.X. Wu, J.G. Wu, V.R. Nerurkar, R. Yanagihara, and Y. Lu. 2008. Inhibition of West Nile virus replication by retrovirus-delivered small interfering RNA in human neuroblastoma. J. Med. Virol. 80:930-936.
? Yang, F.X., A.A. Aguirre, S.W. Jin, B. Wilcox, L. Rougée, M. Yamamoto, Y. Xu, and Y. Lu. 2008. Polybrominated diphenyl ethers in tilapia (Oreochromis mossambicus) from O’ahu, Hawai`i. J. Environ. Monitoring 10:432-434.
? Sniderhan, L.F, A. Stout, Y. Lu, M.V. Chao, and S.B. Maggirwar. 2008. Role of Ankyrin-rich Membrane Spanning Protein in Neurotrophin-mediated Activation of Nuclear Factor-κB Signaling. Molecular and Cellular Neurosci. 38:404-416.
? Yang, F.X., B. Wilcox, S.W. Jin, A. A. Aguirre, L. Rougée, M. Yamamoto, Y. Xu, and Y. Lu. 2008. Concentration and toxic equivalency profile of polychlorinated biphenyls in Tilapia from Hawaiian waters. Chemosphere. 73:133-137.
? Wu, C.X., V.R. Nerurkar, R. Yanagihara, and Y. Lu. 2008. Multiple modifications for improved homologous recombination and high efficiency generation of recombinant adenovirus-based vectors. J. Virological Methods. 153:120-128.
? Lu, Y. 2009. Green fluorescent protein (GFP) – Lentiviral vector targeting for neuroAIDS. In: Hicks B.W. (editor), Methods in Molecular Biology: Viral Applications of the Green Fluorescent Protein. Human Press Inc. New Jersey. Pp 177-199.
? Shekhar, M.S. and Y. Lu. 2009. Application of Nucleic Acid-Based Therapeutics for Viral Infections in Shrimp Aquaculture. Marine Biotechnology. 11:1-9.
? Asahina, A.Y, Y. Lu, C.X. Wu, and P.C. Loh. 2009. Potential biosentinels of human waste in marine coastal waters: Bioaccumulation of human caliciviruses and enteroviruses from sewage polluted waters by indigenous mollusks. J. Virol. Methods. 158:46-50.
? Tan, F., F.X. Yang, W.M. Wang, M Wang, and Y. Lu. 2009. A new fish cell line of fin established from rare minnow as versatile tool in ecotoxicology assessment of cytotoxicity of heavy metals Synechocystis sp. Acta Hydrobioligica Sinica. 33(4):234-238.
? Tan, F.X., M. Wang, W.M. Wang, A.A. Aguirre, B. Wilcox, and Y. Lu. 2009. Validation of an in vitro cytotoxicity test for four heavy metals using cell lines derived from a green sea turtle (Chelonia mydas). Cell Biology and Toxicology. 26(3):255-263.
? Cox, C. S.B. Cao, and Y. Lu. 2009. Enhanced Detection and Study of Murine Norovirus-1 Using a More Efficient Microglial Cell Line. Virol. J. 6:196-.
? Liu, X.Q., M. Wang, W.M. Wang, and Y. Lu. 2009. Studies on the susceptibility of multiple fresh water cell lines to channel catfish virus. J. Hydroecology. 2(6):76-79.
? Yang, Y.B., J.G. Wu, and Y. Lu. 2010. Mechanism of Extracellular HIV-1-TAT Induction of IL-1b from Human Monocytes: Involvement of PLC/PKC signaling Cascade. J. Med. Virol. 82(5):735-746.
? Wu, C.X. and Y. Lu. 2010. High-titer retroviral vector system for efficient gene delivery into human and mouse cells of hematopoietic and lymphocytic lineages. J. Gen. Virol. 91:1909-1918.
? Jin, S.W., F.X. Yang, Y. Hui, Y. Xu, Y. Lu, J.K. Liu. 2010. Cytotoxicity and apoptosis induction on RTG-2 cells of 2,20,4,40-tetrabromodiphenyl 3 ether (BDE-47) and decabrominated diphenyl ether (BDE-209). Toxicology in vitro 24:1190-1196.
? Yasuhara-Bell, J., Y.B. Yang, R. Barlow, H. Trapido-Rosenthal, and Y. Lu. 2010. In vitro evaluation of marine-microorganism extracts for anti-viral activities. Virology Journal. doi:10.1186/1743-422X-7-182.
? Ju, L.W., L.F. Jiang, J.X. Yang, Q. Shi, Q.W. Jiang, H.G. Shen, Y.Y. Tan, and Y. Lu. 2010. Co-infection of influenza A/H1N1 and A/H3N2 viruses in a patient with influenza-like illness during the winter/spring of 2008 in Shanghai, China. J. Med. Virol. 82(8):1299-1305.
? Yasuhara-Bell J and Y. Lu. 2010. Marine compounds and their antiviral activities. Antiviral Research 86:231-240.
? Huang, F.T., S.B. Cao, X.X. Cui, C.X. Xiong, M. Wang, Y.A. Lu, W.M. Wang, J. Ye, X.Q. Liu. 2011. Transduction of fish cells with recombinant baculovirus – New findings from previous studies. J. Virol. Methods. 173:294-299.
? Tong, H.I. and Y. Lu. 2011. Effective detection of human adenovirus in Hawaiian waters using enhanced PCR method. Virol. J. 8:57 (doi:10.1186/1743-422X-8-57).
? Cao, S.B., C.X. Wu, Y.B. Yang, L.F. Sniderhan, S. Maggirwar, S. Dewhurst, and Y. Lu. 2011. Lentiviral vector-mediated expression of sTNFR-Fc in stably transduced human macrophage and neuronal cells: implications for NeuroAIDS therapeutic. J. Neuroinflammation. 8(1):48 (DOI: 10.1186/1742-2094-8-48)
? Viau, E.J., K.D. Goodwin, K.M. Yamahara, B.A. Layton, L.M. Sassoubre, S.L. Burns, H.I. Tong, S.W.C. Wong, Y. Lu, and A.B. Boehm. 2011. Bacterial pathogens in Hawaiian coastal streams - associations with fecal indicators, land cover, and water quality. Water Research. 45(11):3279-90.
? Yang, F.X., S.W. Jin, Y. Xu, and Y. Lu. 2011. Increasing responses of interleukin-8, reactive oxygen species and p53 protein in human lung epithelial cells exposed to PM2.5 collected from an E-waste recycling area in China. Env. Res Lett. 6(2):024013 (doi: 10.1088/1748-9326/6/2/024013).
? Yan, W., P. Nie, and Y. Lu. 2011. Establishment, characterization, and viral susceptibility of a new cell line derived from a goldfish (Carassius auratus) tail fin. Journal of Fish Diseases. 34(10):757-768.
? Tong, H.I., C. Connell, A.B. Boehm, and Y. Lu. 2011. Effective detection of human noroviruses in Hawaiian waters using enhanced RT-PCR methods. Water Research 45(18):5837-5848.
? Wu, B., B.B. Zhu, Y.L. Luo, M. Wang, Y. Lu, W.M. Wang, S.B. Cao, F.T. Huang, and X.Q. Liu. 2011. Generation and characterization of monoclonal antibodies against channel catfish virus. Hybridoma. 30(6): 555-558.
? Ma, C.C., C.M. Burchfiel, J.S. Grove, D. Fekedulegn, Y. Lu, M.E. Andrew, B.J. Willcox, K. Masaki, J.D. Curb, and B.L. Rodriguez. 2011. Risk factors for fractures among Japanese-American men: the Honolulu Heart Program and Honolulu-Asia Aging Study. Osteoporosis Internal. doi:10.1007/s11657-011-0068-6 Key.
? Tong, J., H. Trapido-Rosenthal, J. Wang, Y.W. Wang, Q.X. Li, and Y. Lu. 2012. Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters. Marine Drugs. 10:521-538.
? Tong, J., Y.W. Wang, and Y. Lu. 2012. New Developments in Small Molecular Compounds for Anti-HCV Therapy. J. Zhejiang University Sciences-B. 12(1):56-82.
? Huang, F.T., Q. Li, X.X. Cui, S.B. Cao, C.X. Xiong, M. Wang, Y. Lu, W.M. Wang, J. Ye, and X.Q. Liu. 2011. Characterization of spring viraemia of carp virus glycoprotein expressed by recombinant baculovirus. Virus Gene (in press).
? Connell, C. Tong, H.I., and Y. Lu. 2012. New Approaches for Enhanced Detection of Enteroviruses from Hawaiian Environmental Waters. PLoS ONE (in press).