简介：
　　鲁元安教授自1985年赴美学习，获得美国俄勒冈州立大学微生物学硕士，夏威夷大学病毒学博士和动物病毒学博士后，随后在加州大学洛杉矶分校分子病毒学博士后。现任夏威夷大学公共卫生学院环境与健康学科主任，以及水产动物疾病杂志、世界病毒学杂志和蓝色生物科技期刊编委。
　　鲁教授主要从事病毒学方面的研究，包括建立检测诊断，预防及治疗人类和水产动物病毒的新方法和新思路。作为课题首席研究员在近十年主持承担了20余项研究课题，科研经费总计超过四百万美元，其经费来源于美国NIH, NSF, USDA, SEAGRANT, 及非政府基金机构及夏威夷大学资助项目。应邀参编了4本专著和编写4篇与病毒学有关的综述。在国际病毒学等主流刊物antiviral research, Advances in Virus Research, Journal of Biological Chemistry发表SCI论文共80余篇，其中第一作者27篇，通讯作者45篇。这些论文共被引用648次。 单篇文章平均被引用8.3次，特别是最近发表的几篇文章在国际权威数据库science direct 被列入前十位最热门的文章。在国际学术会议如American Society for Virology, American Society for Microbiology, International Society for Neurovirology发表论文及摘要120余篇。 5次担任国际会议主席，应邀做过38次大会或特邀报告。另应邀在国际国内知名大学和研究所包括Baylor College of Medicine, Fudan University, Wuhan University, and Virology Institute of Chinese Academy of Sciences 学术报告50余次。目前担任4个国际主流学术期刊编委，如Diseases of Aquatic Organisms等，以及33个国际主流学术期刊的选稿及评委包括PloS ONE, Antiviral Research, Cancer letters, Vaccine, and Journal of Medical Virology，还是6个主流国际学术组织成员。鲁教授分别于在2001年和2003年当选为美国微生物学会夏威夷分会主席，并于2003－2005年担任夏威夷大学教师参议员。目前是国内多所知名大学及科研机构的访问教授。

联系方式： ylu@pbrc.hawaii.edu

研究方向：
基因治疗神经艾滋的新途径方法;
研发具抗病毒性的转基因虾品系；
研发以人类肠道病毒作为有效监测水环境污染的新生物指示系统；
从海洋微生物筛选抗病毒的新药物。

主要研究项目及专利：
1、Establishment of PCR array for Quantitative Detection of Multiple Pathogens and Pathogen Indicators from Tropic/Subtropic Coastal Waters
2、Development of Transgenic Shrimp Strains with Viral Resistance
3、Shrimp Promoter Mediated Transgene Expression in Primary Shrimp Cell Cultures in vitro
4、Integrative Training in Ecology, Conservation and Pathogen Biology
5、Development of Gene Transfer Approaches for NeuroAIDS
6、Specialized Neurosciences Research Programs at Minority Research Institutes, National
Institute of Neurological Disorders and Stroke
7、Establishment of Lentiviral Vector Mediated Transduction and Expression of a Potential
Neuro-protective Factor in Mouse Monocytes and Macrophages
8、Isolation and characterization of marine antiviral compounds extracted from marine
9、Molecular cloning and identification of shrimp promoter
10、Isolation and identification of marine anti-viral compounds
11、Establishment and characterization of cell lines from moi
12、Modeling macrophage-based gene therapy for NeuroAIDS

专利名称
Method for Growing Crustacean Virus in Fish Cells
Nucleotide Sequence of Shrimp Actin Promoter and Associated Transcriptional Elements and Their Use in Genetic Transformation Biotechnology

代表性论文
1．Connell, C. Tong, H.I., and Y. Lu. 2012. New Approaches for Enhanced Detection of Enteroviruses from Hawaiian Environmental Waters.  PLoS ONE (in press).
2.Huang, F.T., Q. Li, X.X. Cui, S.B. Cao, C.X. Xiong, M. Wang, Y. Lu, W.M. Wang, J. Ye, and X.Q. Liu. 2011. Characterization of spring viraemia of carp virus glycoprotein expressed by recombinant baculovirus. Virus Gene (in press).
3.Tong, J., Y.W. Wang, and Y. Lu. 2012. New Developments in Small Molecular Compounds for Anti-HCV Therapy.  J. Zhejiang University Sciences-B. 12(1):56-82.
4.Tong, J., H. Trapido-Rosenthal, J. Wang, Y.W. Wang, Q.X. Li, and Y. Lu. 2012. Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters.  Marine Drugs. 10:521-538.
5.Ma, C.C., C.M. Burchfiel, J.S. Grove, D. Fekedulegn, Y. Lu, M.E. Andrew, B.J. Willcox, K. Masaki, J.D. Curb, and B.L. Rodriguez. 2011. Risk factors for fractures among Japanese-American men: the Honolulu Heart Program and Honolulu-Asia Aging Study. Osteoporosis Internal. doi:10.1007/s11657-011-0068-6 Key.
6.Wu, B., B.B. Zhu, Y.L. Luo, M. Wang, Y. Lu, W.M. Wang, S.B. Cao, F.T. Huang, and X.Q. Liu. 2011. Generation and characterization of monoclonal antibodies against channel catfish virus. Hybridoma. 30(6): 555-558.
7.Tong, H.I., C. Connell, A.B. Boehm, and Y. Lu.  2011. Effective detection of human noroviruses in Hawaiian waters using enhanced RT-PCR methods.Water Research 45(18):5837-5848.
8.Yan, W., P. Nie, and Y. Lu. 2011. Establishment, characterization, and viral susceptibility of a new cell line derived from a goldfish (Carassius auratus) tail fin. Journal of Fish Diseases. 34(10):757-768.
9.Yang, F.X., S.W. Jin, Y. Xu, and Y. Lu. 2011. Increasing responses of interleukin-8, reactive oxygen species and p53 protein in human lung epithelial cells exposed to PM2.5 collected from an E-waste recycling area in China. Env. Res Lett. 6(2):024013 (doi: 10.1088/1748-9326/6/2/024013).
10.Viau, E.J., K.D. Goodwin, K.M. Yamahara, B.A. Layton, L.M. Sassoubre, S.L. Burns, H.I. Tong, S.W.C. Wong, Y. Lu, and A.B. Boehm. 2011. Bacterial pathogens in Hawaiian coastal streams - associations with fecal indicators, land cover, and water quality. Water Research. 45(11):3279-90.
11.Cao, S.B., C.X. Wu, Y.B. Yang, L.F. Sniderhan, S. Maggirwar, S. Dewhurst, andY. Lu. 2011. Lentiviral vector-mediated expression of sTNFR-Fc in stably transduced human macrophage and neuronal cells: implications for NeuroAIDS therapeutic. J. Neuroinflammation.  8(1):48 (DOI: 10.1186/1742-2094-8-48)
12.Tong, H.I. and Y. Lu. 2011. Effective detection of human adenovirus in Hawaiian waters using enhanced PCR method. Virol. J. 8:57  (doi:10.1186/1743-422X-8-57).
13.Huang, F.T., S.B. Cao, X.X. Cui, C.X. Xiong, M. Wang, Y.A. Lu, W.M. Wang, J. Ye, X.Q. Liu. 2011. Transduction of fish cells with recombinant baculovirus – New findings from previous studies. J. Virol. Methods. 173:294-299.
14.Yasuhara-Bell J and Y. Lu.  2010. Marine compounds and their antiviral activities. Antiviral Research 86:231-240.
15.Ju, L.W., L.F. Jiang, J.X. Yang, Q. Shi, Q.W. Jiang, H.G. Shen, Y.Y. Tan, and Y. Lu. 2010. Co-infection of influenza A/H1N1 and A/H3N2 viruses in a patient with influenza-like illness during the winter/spring of 2008 in Shanghai, China.J. Med. Virol. 82(8):1299-1305.
16.Yasuhara-Bell, J., Y.B. Yang, R. Barlow, H. Trapido-Rosenthal, and Y. Lu. 2010. In vitro evaluation of marine-microorganism extracts for anti-viral activities.Virology Journal. doi:10.1186/1743-422X-7-182.
17.Jin, S.W., F.X. Yang, Y. Hui, Y. Xu, Y. Lu, J.K. Liu. 2010. Cytotoxicity and apoptosis induction on RTG-2 cells of 2,20,4,40-tetrabromodiphenyl 3 ether (BDE-47) and decabrominated diphenyl ether (BDE-209). Toxicology in vitro24:1190-1196.
18.Wu, C.X. and Y. Lu. 2010. High-titer retroviral vector system for efficient gene delivery into human and mouse cells of hematopoietic and lymphocytic lineages. J. Gen. Virol. 91:1909-1918.
19.Yang, Y.B., J.G. Wu, and Y. Lu. 2010. Mechanism of Extracellular HIV-1-TAT Induction of IL-1b from Human Monocytes: Involvement of PLC/PKC signaling Cascade. J. Med. Virol. 82(5):735-746.
20.Liu, X.Q., M. Wang, W.M. Wang, and Y. Lu. 2009. Studies on the susceptibility of multiple fresh water cell lines to channel catfish virus. J. Hydroecology.  2(6):76-79.
21.Cox, C. S.B. Cao, and Y. Lu.  2009. Enhanced Detection and Study of Murine Norovirus-1 Using a More Efficient Microglial Cell Line.  Virol. J.  6:196-.
22.Tan, F.X., M. Wang, W.M. Wang, A.A. Aguirre, B. Wilcox, and Y. Lu.  2009. Validation of an in vitro cytotoxicity test for four heavy metals using cell lines derived from a green sea turtle (Chelonia mydas). Cell Biology and Toxicology. 26(3):255-263.
23.Tan, F., F.X. Yang, W.M. Wang, M Wang, and Y. Lu. 2009. A new fish cell line of fin established from rare minnow as versatile tool in ecotoxicology assessment of cytotoxicity of heavy metals Synechocystis sp. Acta Hydrobioligica Sinica. 33(4):234-238.
24.Asahina, A.Y, Y. Lu, C.X. Wu, and P.C. Loh. 2009. Potential biosentinels of human waste in marine coastal waters: Bioaccumulation of human caliciviruses and enteroviruses from sewage polluted waters by indigenous mollusks. J. Virol. Methods. 158:46-50.
25.Shekhar, M.S. and Y. Lu.  2009. Application of Nucleic Acid-Based Therapeutics for Viral Infections in Shrimp Aquaculture. Marine Biotechnology. 11:1-9.
26.Lu, Y.  2009. Green fluorescent protein (GFP) – Lentiviral vector targeting for neuroAIDS. In: Hicks B.W. (editor), Methods in Molecular Biology: Viral Applications of the Green Fluorescent Protein. Human Press Inc. New Jersey. Pp 177-199.
27.Wu, C.X., V.R. Nerurkar, R. Yanagihara, and Y. Lu.  2008. Multiple modifications for improved homologous recombination and high efficiency generation of recombinant adenovirus-based vectors. J. Virological Methods. 153:120-128.
28.Yang, F.X., B. Wilcox, S.W. Jin, A. A. Aguirre, L. Rougée, M. Yamamoto, Y. Xu, and Y. Lu. 2008. Concentration and toxic equivalency profile of polychlorinated biphenyls in Tilapia from Hawaiian waters.  Chemosphere. 73:133-137.
29.Sniderhan, L.F, A. Stout, Y. Lu, M.V. Chao, and S.B. Maggirwar. 2008. Role of Ankyrin-rich Membrane Spanning Protein in Neurotrophin-mediated Activation of Nuclear Factor-κB Signaling. Molecular and Cellular Neurosci. 38:404-416.
30.Yang, F.X., A.A. Aguirre, S.W. Jin, B. Wilcox, L. Rougée, M. Yamamoto, Y. Xu, andY. Lu. 2008. Polybrominated diphenyl ethers in tilapia (Oreochromis mossambicus) from O’ahu, Hawai`i. J. Environ. Monitoring 10:432-434.
31.Yang, Y.B., C.X.  Wu, J.G. Wu, V.R. Nerurkar, R. Yanagihara, and Y. Lu.  2008. Inhibition of West Nile virus replication by retrovirus-delivered small interfering RNA in human neuroblastoma. J. Med. Virol. 80:930-936.
32.Lu, Y. and L. Sniderhan. 2008.  Viral vector mediated gene transfer. In: Schwab M. (editor), Encyclopedia of Cancer. 2nd Edition. Springer-Verlag Berlin Heidelberg, New York. pp 3169-3171. Pubmed 10.1007/978-3-540-47648-1_6193.
33.Tan, F, M. Wang, W. Wang, and Y. Lu.  2008. Cytotoxicity sensitivity of six fish cell lines to four common heavy metals. Toxicology in Vitro. 22:164-170.